Western Blot IL23 R Antibody (15N6C6) NBP Analysis using IL23 receptor antibody Lysate from (A) human HCT116, (B) Jurkat and C) mouse NIH 3T3 cells probed with IL23 receptor antibody at 1 ug/mL Western Blot IL23 R Antibody (15N6C6) NBP Analysis using Azide Free version of NBPThe functional IL23 receptor complex consists of two receptor subunits, the IL12 receptor beta 1 subunit (IL12 R beta 1) and the IL23specific receptor subunit (IL23 R) (3) Mouse IL23 R cDNA encodes a 644 amino acid (aa) type I transmembrane protein with a 23 aa residue signal peptide, a 349 aa residue extracellular domain, a 23 aaIL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis Tissue specificity Expressed by monocytes, Th1, Th0, NK and dendritic cells
Anti Il 23 Receptor Monoclonal Antibody Prevents Cd4 T Cell Mediated Colitis In Association With Decreased Systemic Th1 And Th17 Responses Semantic Scholar
Il-23 receptor antibody
Il-23 receptor antibody-AntiIL23R antibodies are offered by a number of suppliers This target gene encodes the protein 'interleukin 23 receptor' in humans and may also be known as IL23 receptor Structurally, the protein is reported to be 717 kilodaltons in mass Based on gene name, canine, porcine, monkey, mouse and rat orthologs may also be foundInterleukin23 (IL23) is known to play a crucial role in the development and maintenance of T helper 17 cells It has been previously demonstrated that IL17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria However, the precise role of the IL23 receptor (IL23R) for the B burgdorferiinduced IL17 responses or human Lyme disease has not yet been elucidated
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74 Interleukin 23 Receptor (IL23R) Antibodies from 15 manufacturers are available on wwwantibodiesonlinecomKLH conjugated synthetic peptide derived between amino acids of human IL23 Receptor Target IL23 Receptor Alternative Names (click to expand) antiIL23 Receptor antibody, antiIL23R antibody, antiinterleukin 23 receptor antibodyDrugscom provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment Data sources include IBM Watson Micromedex (updated 6 Jan 21), Cerner Multum™ (updated 4 Jan 21), ASHP (updated 6 Jan 21
It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of Tcells called TH17 cells A functional receptor for IL23 (the IL23 receptor) has been identified and is composed of IL12Rβ1 and IL23R IL23 is expressed chiefly by the macrophages and DCsHere, to clarify the contribution of IL12 and IL23 in T cellmediated colitis, we compared the efficacy of a monoclonal antibody (mAb) to an IL23specific receptor subunit with that of an antiIL12/23p40 mAb in a naive CD4 T cell transfer model of experimental colitis, which is associated with enhanced Th1 and Th17 responses BothIL23 Receptor Gene IL23R gene / cDNA is a proteincoding gene which located on 1p313 The IL23R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken163 organisms have orthologs with human gene IL23R
ProblemTo provide an antihuman IL23R antibody that has excellent activity and/or species crossreactivity as compared to conventional antihuman IL23R antibodies, and to provide means using the antibody for preventing or treating various types of diseases in which human IL23R is involved in pathogenesis Solution An antihuman IL23R antibody containing both a heavy chain variableThe protein encoded by this gene is a subunit of the receptor for IL23A/IL23 This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a liganddependent mannerInterleukin23 is a heterodimeric cytokine composed of an IL12B subunit and the IL23A subunit IL23 is part of IL12 family of cytokines A functional receptor for IL23 has been identified and is composed of IL12R β1 and IL23R Adnectin2 is binding to IL23 and compete with IL23/IL23R mRNA of IL23R is 2,8 kB in length and includes 12 exons The translated protein contains 629 amino acids, which is a type I penetrating protein includes signal peptide, an Nterminal fibronectin III
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Here, to clarify the contribution of IL12 and IL23 in T cellmediated colitis, we compared the efficacy of a monoclonal antibody (mAb) to an IL23specific receptor subunit with that of an antiIL12/23p40 mAb in a naive CD4 T cell transfer model of experimental colitis, which is associated with enhanced Th1 and Th17 responsesIL23 Receptor Gene IL23R gene / cDNA is a proteincoding gene which located on 1p313 The IL23R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken163 organisms have orthologs with human gene IL23RIL23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines IL23 is composed of the IL12p40 soluble receptor subunit and a novel cytokinelike subunit related to IL12p35, termed p19 IL23 mediates it cellular function by binding to IL23 receptor, which pairs with IL12Rb1 to confer IL23 responsiveness
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Problem To provide an antihuman IL23R antibody with excellent activity and/or species crossreactivity as compared to conventional antihuman IL23R antibodies;And a means for preventing or treating, using the antibody, various types of diseases where human IL23R contributes to pathogenesis, such as ophthalmological disorders, inflammatory enteropathy, or psoriasisInterleukin23 (IL23) is a heterodimeric cytokine composed of an IL12B subunit (that is shared with IL12) and the IL23A subunit IL23 is part of IL12 family of cytokines A functional receptor for IL23 (the IL23 receptor) has been identified and is composed of IL12R β1 and IL23R Adnectin2 is binding to IL23 and compete with IL23/IL23R mRNA of IL23R is 2,8 kB in length and
Shifting The Focus The Primary Role Of Il 23 In Psoriasis And Other Inflammatory Disorders Gooderham 18 Journal Of The European Academy Of Dermatology And Venereology Wiley Online Library
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The AntiIL23 Receptor antibody was generated using interleukin 23 receptor as the antigen The AntiIL23 Receptor antibody from GeneTex is a Rabbit Polyclonal antibody to IL23 Receptor The AntiIL23 Receptor antibody Recognizes Human The AntiIL23 Receptor antibody has been validated for the following Applications WBReceptor tyrosineprotein kinase erbB2 (ErbB2/Her2) VAkt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Nuclear FactorKB P65 (NFkBP65) Estrogen Receptor 1 (ESR1) Albumin (ALB) Interferon gamma (IFNG) IL23 antibody il23p19 antibody p19 antibodyThis antibody recognizes an epitope within the Nterminal region of Interleukin23 receptor, precsent in isoforms 1, 3 and 4 (UniProt Q5VWK5), the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence
Functional Studies On The Ibd Susceptibility Gene Il23r Implicate Reduced Receptor Function In The Protective Genetic Variant R381q
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The protein encoded by this gene is a subunit of the receptor for IL23A/IL23 This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a liganddependent mannerAgonist antibodies to IL23 receptor Download PDF Info Prior art keywords antibody wound seq antigen healing Prior art date Legal status (The legal status is an assumption and is not a legal conclusion Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed)AntiIL23R antibodies are offered by a number of suppliers This target gene encodes the protein 'interleukin 23 receptor' in humans and may also be known as IL23 receptor Structurally, the protein is reported to be 717 kilodaltons in mass Based on gene name, canine, porcine, monkey, mouse and rat orthologs may also be found
Frontiers Mini Review New Treatments In Psoriatic Arthritis Focus On The Il 23 17 Axis Pharmacology
The Protective And Pathogenic Roles Of Il 17 In Viral Infections Friend Or Foe Open Biology
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